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Stabilisation of Peptide Foldamers in an Aqueous Medium by Incorporation of Azapeptide Building Blocks
Author(s) -
Hetényi Anasztázia,
Tóth Gábor K.,
Somlai Csaba,
Vass Elemér,
Martinek Tamás A.,
Fülöp Ferenc
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200900724
Subject(s) - aqueous medium , chemistry , hydrogen bond , aqueous solution , computer science , combinatorial chemistry , crystallography , information retrieval , organic chemistry , molecule
Stable foldamers in water : Helical peptidic foldamers including H12 and H10/12 helices were constructed and stabilised in water. The foldamers' extra rigidity stems from the strong hydrogen bonding network of the azapeptide groups (see graphic).