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Guest Binding Drives Reversible Atropisomerism in Cavitand Hosts
Author(s) -
Nguyen Thanh V.,
Sinclair David J.,
Willis Anthony C.,
Sherburn Michael S.
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200900695
Subject(s) - cavitand , atropisomer , substituent , affinities , chemistry , solvent polarity , solvent , binding affinities , stereochemistry , crystallography , organic chemistry , receptor , crystal structure , biochemistry , supramolecular chemistry
Abstract Guest‐love‐ometer : The equilibrium inside – outside atropisomeric ratio of ortho ‐substituted phenyl cavitands shows a strong solvent dependence. The competition between the ortho ‐substituent and the solvent guest for the bowl cavity leads to a sensitive system for the measurement of relative guest binding affinities.