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Helical Chiral Pyridine N ‐Oxides: A New Family of Asymmetric Catalysts
Author(s) -
Chen Jinshui,
Takenaka Norito
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200900607
Subject(s) - enantioselective synthesis , pyridine , optically active , catalysis , nucleophile , chemistry , combinatorial chemistry , alkyl , pyridine n oxide , ring (chemistry) , epoxide , organic chemistry
Optically active chiral alkyl chlorides are valuable compounds because of their bioactivity and versatile synthetic utility. Accordingly, the ring opening of epoxides with a chloride nucleophile stands as an important goal in asymmetric catalysis. We describe herein recent advances in the design and development of chiral pyridine N ‐oxide catalysts for the enantioselective synthesis of chlorohydrins.