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Hybrid Organic–Inorganic Silica Gel Carriers with Controlled Drug‐Delivery Properties
Author(s) -
Contessotto Laura,
Ghedini Elena,
Pinna Francesco,
Signoretto Michela,
Cerrato Giuseppina,
Crocellà Valentina
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200900603
Subject(s) - drug delivery , drug carrier , sol gel , chemistry , materials science , nanotechnology
Pure and modified silica materials were synthesised by a sol–gel process and used as carrier for the controlled release of ibuprofen, selected as model drug. A one‐step synthesis was optimised for the preparation of various silica–drug composites by using tetraethoxysilane and 3‐aminopropyltriethoxysilane as precursors at different molar ratios. The presence of aminopropyl groups on the silica surface influences the drug‐delivery rate leading to a high degree the desorption process controlled.