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Application of Copper(II)–Dipyridylphosphine Catalyst in the Asymmetric Hydrosilylation of Simple Ketones in Air
Author(s) -
Zhang XiChang,
Wu Yan,
Yu Feng,
Wu FeiFei,
Wu Jing,
S. C. Chan Albert
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200900499
Subject(s) - copper , hydrosilylation , catalysis , chemistry , salt (chemistry) , ketone , organic chemistry , combinatorial chemistry
Ask a copper : A copper(II) salt/chiral dipyridylphosphine/PhSiH 3 system (see scheme) acts as a very effective and practical catalyst for the asymmetric reduction of heteroaromatic and other types of ketones in air with good‐to‐excellent enantioselectivities (up to 94 %), giving many chiral alcohols that are intermediates for physiologically active compounds. Remarkable temperature effects were observed for some heteroaromatic ketones.