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Highly Enantio‐ and Diastereoselective Organocatalytic Desymmetrization of Prochiral Cyclohexanones by Simple Direct Aldol Reaction Catalyzed by Proline
Author(s) -
Companyó Xavier,
Valero Guillem,
Crovetto Luis,
Moyano Albert,
Rios Ramon
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200900488
Subject(s) - desymmetrization , aldol reaction , proline , chemistry , catalysis , organocatalysis , panacea (medicine) , organic chemistry , combinatorial chemistry , enantioselective synthesis , biochemistry , amino acid , pathology , medicine , alternative medicine
Abstract Panacea for aldol desymmetrizations : We describe an easy entry for the desymmetrization of 4‐substituted‐cyclohexanones catalyzed by proline, using as cocatalysts different hydrogen‐bonding donors (see scheme), which dramatically improves the catalytic efficiency of proline in desymmetrization reactions.