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Low‐Molecular‐Weight Dendrons for DNA Binding and Release by Reduction‐Triggered Degradation of Multivalent Interactions
Author(s) -
Kostiainen Mauri A.,
Rosilo Henna
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200900420
Subject(s) - degradation (telecommunications) , reduction (mathematics) , chemistry , dna , biophysics , biochemistry , computer science , biology , telecommunications , geometry , mathematics
Losing the grip : The synthesis of multivalent low‐molecular‐weight dendrons with lysine branching units coupled to disulfide‐linked spermine surface groups is described. It is furthermore demonstrated that the dendrons bind DNA with good affinity (see image), but are also able to release the DNA in a reductive environment.