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Electrochemical Genotyping by Using Two Ferrocene/Isoquinoline‐Connected DNA Probes with Different Redox Potentials on a Single Electrode
Author(s) -
Ikeda Reona,
Kitagawa Satoshi,
Chiba Junya,
Inouye Masahiko
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200900368
Subject(s) - isoquinoline , ferrocene , genotyping , electrode , electrochemistry , redox , combinatorial chemistry , dna , conjugate , chemistry , polymorphism (computer science) , analytical chemistry (journal) , allele , biochemistry , genotype , stereochemistry , inorganic chemistry , chromatography , gene , mathematics , mathematical analysis
A single electrode : We describe an electrochemical single‐nucleotide polymorphism genotyping protocol using a single electrode that is modified with a ferrocene/isoquinoline conjugate connected to DNA probes, which possess different redox potentials. Three types of zygotes (a wild‐type homozygote, a mutant homozygote, and a heterozygote) were identified by a single square wave voltammetric measurement.