Electrochemical Genotyping by Using Two Ferrocene/Isoquinoline‐Connected DNA Probes with Different Redox Potentials on a Single Electrode | Zendy

Ikeda Reona | Zendy; Kitagawa Satoshi | Zendy; Chiba Junya | Zendy; Inouye Masahiko | Zendy

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Electrochemical Genotyping by Using Two Ferrocene/Isoquinoline‐Connected DNA Probes with Different Redox Potentials on a Single Electrode

Author(s) -

Ikeda Reona,

Kitagawa Satoshi,

Chiba Junya,

Inouye Masahiko

Publication year - 2009

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.200900368

Subject(s) - isoquinoline , ferrocene , genotyping , electrode , electrochemistry , redox , combinatorial chemistry , dna , conjugate , chemistry , polymorphism (computer science) , analytical chemistry (journal) , allele , biochemistry , genotype , stereochemistry , inorganic chemistry , chromatography , gene , mathematics , mathematical analysis

A single electrode : We describe an electrochemical single‐nucleotide polymorphism genotyping protocol using a single electrode that is modified with a ferrocene/isoquinoline conjugate connected to DNA probes, which possess different redox potentials. Three types of zygotes (a wild‐type homozygote, a mutant homozygote, and a heterozygote) were identified by a single square wave voltammetric measurement.

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