A  N,N′ ‐Dioxide–Copper(II) Complex as an Efficient Catalyst for the Enantioselective and Diastereoselective Mannich‐Type Reaction of Glycine Schiff Bases with Aldimines | Zendy

Shang Deju | Zendy; Liu Yanling | Zendy; Zhou Xin | Zendy; Liu Xiaohua | Zendy; Feng Xiaoming | Zendy

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A N,N′ ‐Dioxide–Copper(II) Complex as an Efficient Catalyst for the Enantioselective and Diastereoselective Mannich‐Type Reaction of Glycine Schiff Bases with Aldimines

Author(s) -

Shang Deju,

Liu Yanling,

Zhou Xin,

Liu Xiaohua,

Feng Xiaoming

Publication year - 2009

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.200900118

Subject(s) - enantioselective synthesis , aldimine , schiff base , catalysis , chemistry , glycine , copper , mannich reaction , organic chemistry , polymer chemistry , medicinal chemistry , amino acid , biochemistry

Mild mannered! A highly diastereo‐ and enantioselective Mannich‐type reaction of glycine Schiff base 1 has been developed by using the N,N′ ‐dioxide L ‐Cu II complex as a catalyst. Various optically active anti‐ α,β‐diamino acid esters were obtained in good yields with up to 96:4 d.r. and 97 % ee. This straightforward method features a low catalyst loading and mild reaction conditions.

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