Synthesis of Spiroheterocycles by Palladium‐Catalyzed Domino Cycloisomerization/Cross‐Coupling of α‐Allenols and Baylis–Hillman Acetates | Zendy

Alcaide Benito | Zendy; Almendros Pedro | Zendy; Martínez del Campo Teresa | Zendy; Quirós M. Teresa | Zendy

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Synthesis of Spiroheterocycles by Palladium‐Catalyzed Domino Cycloisomerization/Cross‐Coupling of α‐Allenols and Baylis–Hillman Acetates

Author(s) -

Alcaide Benito,

Almendros Pedro,

Martínez del Campo Teresa,

Quirós M. Teresa

Publication year - 2009

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.200900096

Subject(s) - allene , moiety , cycloisomerization , domino , adduct , methyl acrylate , chemistry , catalysis , palladium , acrylate , cascade reaction , organic chemistry , medicinal chemistry , monomer , copolymer , polymer

First insights into the reaction between a Baylis–Hillman adduct and an allene moiety have been obtained from the novel domino heterocyclization/cross‐coupling reaction of α‐allenols and Baylis–Hillman acetates, which furnishes [(2,5‐dihydrofuran‐3‐yl)methyl]acrylate derivatives in moderate to good yields.

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