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Synthesis of Spiroheterocycles by Palladium‐Catalyzed Domino Cycloisomerization/Cross‐Coupling of α‐Allenols and Baylis–Hillman Acetates
Author(s) -
Alcaide Benito,
Almendros Pedro,
Martínez del Campo Teresa,
Quirós M. Teresa
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200900096
Subject(s) - allene , moiety , cycloisomerization , domino , adduct , methyl acrylate , chemistry , catalysis , palladium , acrylate , cascade reaction , organic chemistry , medicinal chemistry , monomer , copolymer , polymer
First insights into the reaction between a Baylis–Hillman adduct and an allene moiety have been obtained from the novel domino heterocyclization/cross‐coupling reaction of α‐allenols and Baylis–Hillman acetates, which furnishes [(2,5‐dihydrofuran‐3‐yl)methyl]acrylate derivatives in moderate to good yields.