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Highly Enantioselective Zinc/Amino Alcohol‐Catalyzed Alkynylation of Aldehydes
Author(s) -
Zhong JiangChun,
Hou ShiCong,
Bian QingHua,
Yin MinMin,
Na RiSong,
Zheng Bing,
Li ZhiYuan,
Liu ShangZhong,
Wang Min
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200900070
Subject(s) - enantioselective synthesis , alkynylation , zinc , alcohol , catalysis , chemistry , organic chemistry
Meeting the challenge : The zinc/amino alcohol catalyzed enantioselective addition of terminal alkynes to aldehydes is effective with both phenylacetylene and methyl propiolate, leading to chiral secondary propargyl alcohols with very high enantioselectivity (see scheme).