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Direct Catalytic Asymmetric Synthesis of Highly Functionalized 2‐Methylchroman‐2,4‐diols via Barbas–List Aldol Reaction
Author(s) -
Ramachary Dhevalapally B.,
Sakthidevi Rajasekar
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200900066
Subject(s) - aldol reaction , lactol , chemistry , acetone , catalysis , proline , organic chemistry , combinatorial chemistry , lactone , amino acid , biochemistry
A practical and sustainable chemical process for the synthesis of highly substituted aldol↔lactol products was achieved for the first time through the asymmetric Barbas–List aldol (BLA) reaction of 2‐hydroxybenzaldehydes with acetone in the presence of a catalytic amount of trans ‐4‐OH‐ L ‐proline (see scheme).
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