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Silver‐Ion‐Mediated DNAzyme Switch for the Ultrasensitive and Selective Colorimetric Detection of Aqueous Ag + and Cysteine
Author(s) -
Li Tao,
Shi Lili,
Wang Erkang,
Dong Shaojun
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200900056
Subject(s) - deoxyribozyme , cysteine , chemistry , cytosine , aqueous solution , selectivity , ion , combinatorial chemistry , nanotechnology , detection limit , photochemistry , inorganic chemistry , materials science , biochemistry , chromatography , dna , catalysis , organic chemistry , enzyme
Two states, two applications! An Ag + ‐mediated DNAzyme switch has been designed to detect Ag + and cysteine with high sensitivity and selectivity. In the closed state, Ag + turns on the switch through the formation of cytosine–Ag + –cytosine base pairs, whereas adding cysteine turns off the open switch because it competitively binds to Ag + . This feature endows the DNAzyme switch with two sensing applications.