Silver‐Ion‐Mediated DNAzyme Switch for the Ultrasensitive and Selective Colorimetric Detection of Aqueous Ag +  and Cysteine | Zendy

Li Tao | Zendy; Shi Lili | Zendy; Wang Erkang | Zendy; Dong Shaojun | Zendy

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Silver‐Ion‐Mediated DNAzyme Switch for the Ultrasensitive and Selective Colorimetric Detection of Aqueous Ag + and Cysteine

Author(s) -

Li Tao,

Shi Lili,

Wang Erkang,

Dong Shaojun

Publication year - 2009

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.200900056

Subject(s) - deoxyribozyme , cysteine , chemistry , cytosine , aqueous solution , selectivity , ion , combinatorial chemistry , nanotechnology , detection limit , photochemistry , inorganic chemistry , materials science , biochemistry , chromatography , dna , catalysis , organic chemistry , enzyme

Two states, two applications! An Ag + ‐mediated DNAzyme switch has been designed to detect Ag + and cysteine with high sensitivity and selectivity. In the closed state, Ag + turns on the switch through the formation of cytosine–Ag + –cytosine base pairs, whereas adding cysteine turns off the open switch because it competitively binds to Ag + . This feature endows the DNAzyme switch with two sensing applications.

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