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Cover Picture: The Synthesis of Azadirachtin: A Potent Insect Antifeedant (Chem. Eur. J. 34/2008)
Author(s) -
Ley Steven V.,
AbadSomovilla Antonio,
Anderson James C.,
Ayats Carles,
Bänteli Rolf,
Beckmann Edith,
Boyer Alistair,
Brasca Maria G.,
Brice Abigail,
Broughton Howard B.,
Burke Brenda J.,
Cleator Ed,
Craig Donald,
Denholm Alastair A.,
Denton Ross M.,
DurandReville Thomas,
Gobbi Luca B.,
Göbel Michael,
Gray Brian Lawrence,
Grossmann Robert B.,
Gutteridge Claire E.,
Hahn Norbert,
Harding Sarah L.,
Jennens David C.,
Jennens Lynn,
Lovell Peter J.,
Lovell Helen J.,
de la Puente Mary L.,
Kolb Hartmuth C.,
Koot WinJan,
Maslen Sarah L.,
McCusker Catherine F.,
Mattes Amos,
Pape Andrew R.,
Pinto Andrea,
Santafianos Dinos,
Scott James S.,
Smith Stephen C.,
Somers Andrew Q.,
Spilling Christopher D.,
Stelzer Frank,
Toogood Peter L.,
Turner Richard M.,
Veitch Gemma E.,
Wood Anthony,
Zumbrunn Cornelia
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200890139
Subject(s) - stereocenter , azadirachtin , stereochemistry , chemistry , enantiomer , natural product , catalysis , organic chemistry , enantioselective synthesis , biology , pesticide , agronomy
An exceptionally challenging synthesis target has finally met its match. An avenue of neem trees flanks an outline of the Ley azadirachtin synthesis road map. The neem tree is the natural source of azadirachtin—a potent insect‐feeding suppressant that is widely used in pest control. The highly complex natural product contains sixteen contiguous stereogenic centres, seven of which are tetrasubstituted carbon atoms. Full details of the chemistry used to shape a route to this fascinating target are discussed by S. V. Ley et al. on page 10683 ff. Photographs: William M. Ciesla, www.forestryimages.com; design: Alistair Boyer.