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Highly Enantioselective 1,4‐Addition of Diethyl Phosphite to Enones Using a Dinuclear Zn Catalyst
Author(s) -
Zhao Depeng,
Yuan Ye,
Chan Albert S. C.,
Wang Rui
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200802688
Subject(s) - phosphonate , enantioselective synthesis , catalysis , chemistry , zinc , michael reaction , combinatorial chemistry , organic chemistry , medicinal chemistry
Zinc benefits : The first catalytic asymmetric phospha‐Michael addition of enones has been developed. Under mild reaction conditions, the γ‐oxo phosphonates could be obtained in high yields (up to 99 %) with excellent enantioselectivities (93–99 % ee ; see scheme). The strategy makes the asymmetric synthesis of biologically important phosphonate compounds more accessible.