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A General Palladium‐Catalyzed Amination of Aryl Halides with Ammonia
Author(s) -
Schulz Thomas,
Torborg Christian,
Enthaler Stephan,
Schäffner Benjamin,
Dumrath Andreas,
Spannenberg Anke,
Neumann Helfried,
Börner Armin,
Beller Matthias
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200802678
Subject(s) - phosphine , catalysis , palladium , halide , amination , aryl , ammonia , chemistry , ligand (biochemistry) , organic chemistry , inorganic chemistry , polymer chemistry , biochemistry , alkyl , receptor
A new robust palladium/phosphine catalyst system for the selective monoarylation of ammonia with different aryl bromides and chlorides has been developed. The active catalyst is formed in situ from [Pd(OAc) 2 ] and air‐ and moisture‐stable phosphines as easy‐to‐handle pre‐catalysts. The productivity of the catalyst system is comparable to that of competitive Pd/phosphine systems; full conversion is achieved with most substrates with 1–2 mol % of Pd source and a fourfold excess of ligand (L).