Synthesis of Two Bioactive Natural Products: FR252921 and Pseudotrienic Acid B | Zendy

Amans Dominique | Zendy; Bellosta Véronique | Zendy; Cossy Janine | Zendy

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Synthesis of Two Bioactive Natural Products: FR252921 and Pseudotrienic Acid B

Author(s) -

Amans Dominique,

Bellosta Véronique,

Cossy Janine

Publication year - 2009

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.200802649

Subject(s) - natural (archaeology) , chemistry , biology , paleontology

Jackpot: Two for one! Concise and highly convergent syntheses of the immunosuppressive agent FR252921 and the related antimicrobial natural product pseudotrienic acid B were achieved from one common intermediate by using optically active titanium complexes to control the configuration of the stereogenic centers, a highly stereo‐ and regioselective cross‐metathesis to generate the triene moieties, and a Stille cross‐coupling to install the dienic units.Concise and highly convergent syntheses of the immunosuppressive agent FR252921 and the related antimicrobial natural product pseudotrienic acid B were achieved from a common intermediate by using optically active titanium complexes to control the configuration of the stereogenic centers, a highly stereo‐ and regioselective cross‐metathesis to generate the triene moieties, and a Stille cross‐coupling to install the dienic units.

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