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Synthesis of Two Bioactive Natural Products: FR252921 and Pseudotrienic Acid B
Author(s) -
Amans Dominique,
Bellosta Véronique,
Cossy Janine
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200802649
Subject(s) - natural (archaeology) , chemistry , biology , paleontology
Jackpot: Two for one! Concise and highly convergent syntheses of the immunosuppressive agent FR252921 and the related antimicrobial natural product pseudotrienic acid B were achieved from one common intermediate by using optically active titanium complexes to control the configuration of the stereogenic centers, a highly stereo‐ and regioselective cross‐metathesis to generate the triene moieties, and a Stille cross‐coupling to install the dienic units.Concise and highly convergent syntheses of the immunosuppressive agent FR252921 and the related antimicrobial natural product pseudotrienic acid B were achieved from a common intermediate by using optically active titanium complexes to control the configuration of the stereogenic centers, a highly stereo‐ and regioselective cross‐metathesis to generate the triene moieties, and a Stille cross‐coupling to install the dienic units.