Iridium‐Catalyzed Asymmetric Hydrogenation of Unfunctionalized Enamines | Zendy

Baeza Alejandro | Zendy; Pfaltz Andreas | Zendy

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Iridium‐Catalyzed Asymmetric Hydrogenation of Unfunctionalized Enamines

Author(s) -

Baeza Alejandro,

Pfaltz Andreas

Publication year - 2009

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.200802576

Subject(s) - iridium , chemistry , catalysis , asymmetric hydrogenation , aryl , enantiomer , optically active , organic chemistry , catalytic hydrogenation , medicinal chemistry , polymer chemistry , enantioselective synthesis , alkyl

Optically active tertiary amines are readily prepared by iridium‐catalyzed asymmetric hydrogenation of unfunctionalized enamines (see scheme). The best enantioselectivities with >90 % ee were obtained with N‐ aryl‐ and N‐ benzyl‐substituted enamines with a terminal double bond. The hydrogenation of enamines derived from cyclic ketones, which has not been reported yet with other catalysts, gave enantiomeric excesses of up to 87 %.

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