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Cobalt‐Catalyzed N‐Arylation of Nitrogen Nucleophiles in Water
Author(s) -
Teo YongChua,
Chua GuanLeong
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200802483
Subject(s) - nucleophile , catalysis , cobalt , chemistry , indole test , aryl , pyrazole , nitrogen , halide , combinatorial chemistry , organic chemistry , medicinal chemistry , alkyl
Cobalt ′n′ cross‐coupling! A facile and practical strategy catalyzed by CoCl 2 ⋅ 6 H 2 O has been developed for the N‐arylation of nitrogen nucleophiles with substituted aryl halides in water. The protocol is very simple and requires only mild conditions. A variety of nitrogen nucleophiles, including pyrazole, indole, and 7‐azaindole, undergo catalysis to afford N‐arylated products in moderate to good yields (up to 86 %; see scheme).