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Negishi Cross‐Couplings Compatible with Unprotected Amide Functions
Author(s) -
Manolikakes Georg,
Dong M.Sc. Zhibing,
Mayr Herbert,
Li Jinshan,
Knochel Paul
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200802349
Subject(s) - negishi coupling , amide , aryl , reagent , chemistry , combinatorial chemistry , zinc , stereochemistry , medicinal chemistry , organic chemistry , alkyl
Mild mannered : Unprotected amides and sulfonamides containing aryl bromides and iodides undergo, in the presence of S‐PHOS, smooth Negishi cross‐couplings with various zinc organometallic reagents, allowing the preparation of pharmaceutically relevant molecules (see scheme; S‐PHOS=2‐dicyclohexylphosphino‐2′,6′‐dimethoxybiphenyl).