Diaminoterephthalates: Scaffolds for Combinatorial Chemistry

Fluorescent building blocks : Tetracarboxyamides with a central fluorescent diaminoterephthalate unit were prepared from succinyl succinates following a combinatorial‐like strategy. The 2,5‐diaminoterephthalates (see scheme; PG=protecting group) possess four points of diversification and are introduced as new scaffolds for combinatorial chemistry.2,5‐Diaminoterephthalates that possess four points of diversification are introduced as new scaffolds for combinatorial chemistry. A straightforward synthesis of an orthogonally protected platform compound was developed. This platform was transformed by stepwise deprotection and amidation of the two amino and two carboxylic acid moieties into tetra‐amides with a central aromatic ring as a fluorescence chromophore.