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Selective Chromofluorogenic Sensing of Heparin by using Functionalised Silica Nanoparticles Containing Binding Sites and a Signalling Reporter
Author(s) -
Climent Estela,
Calero Pilar,
Marcos M. Dolores,
MartínezMáñez Ramón,
Sancenón Félix,
Soto Juan
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200802074
Subject(s) - nanoparticle , heparin , protonation , chemistry , combinatorial chemistry , thiol , aqueous solution , surface modification , nanotechnology , organic chemistry , materials science , ion , biochemistry
Heparin detective : Silica nanoparticles functionalised with ion‐channel scaffolds were prepared and used for the chromofluorogenic sensing of heparin in aqueous environments (see figure). The surface of the nanoparticles was functionalised with polyamines (binding sites) and thiols. The reaction of a dye (squaraine) with the surface thiol groups was selectively inhibited by the coordination of heparin with the partly protonated polyamines.