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A Highly Site‐, Regio‐, and Stereoselective Lewis Acid Catalyzed Formal [3+3] Cycloaddition of Methylenecyclopropane‐1,1‐Diesters with C,N‐Diarylnitrones
Author(s) -
Hu Bao,
Zhu Jianlin,
Xing Siyang,
Fang Jie,
Du Ding,
Wang Zhongwen
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200801990
Subject(s) - methylenecyclopropane , cycloaddition , stereoselectivity , chemistry , lewis acids and bases , catalysis , stereochemistry , medicinal chemistry , organic chemistry
Another pathway : A new type of Lewis acid promoted [3+3] cycloaddition of methylenecyclopropane‐1,1‐diesters with C,N‐diarylnitrones is disclosed. This cycloaddition is highly site‐, regio‐, and stereoselective and proceeds in moderate‐to‐excellent yields. A three‐component one‐pot version of the cycloaddition is also reported.