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The First Enantioselective Addition of Diethylzinc to Aldehydes in Ionic Liquids Catalysed by a Recyclable Ion‐Tagged Diphenylprolinol
Author(s) -
Lombardo Marco,
Chiarucci Michel,
Trombini Claudio
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200801984
Subject(s) - diethylzinc , enantioselective synthesis , ionic liquid , catalysis , enantiomer , chemistry , organic chemistry , computer science , combinatorial chemistry
Outstanding recyclability : An ion‐tagged diphenylprolinol efficiently catalyses the first asymmetric addition of diethylzinc to aldheydes in ionic liquids (see figure). Besides good yields and enantiomeric excesses obtained by using only a small excess of alkylating agent, the catalytic system was successfully recycled ten times with no loss of efficiency and catalytic activity.