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First Synthesis of 1‐Chlorovinyl Allenes via Palladium‐Catalyzed Allenylation of Alkynoates with Propargyl Alcohols
Author(s) -
Jiang Huanfeng,
Liu Xiaohang,
Zhou Lei
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200801843
Subject(s) - propargyl , reagent , alkyne , chemistry , catalysis , combinatorial chemistry , palladium , organic chemistry , medicinal chemistry
Water and water only : A novel allenylation reaction of alkynoates was found to take place “on water” by using inactivated propargyl alcohols as allenylating reagents (see scheme). This reaction proceeds by selective sequential insertion of two different alkynes, which might be as a result of the leaving group (‐OH) on one of the alkyne molecules.