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Organocatalyzed Highly Enantioselective Michael Additions of Malonates to Enones by Using Novel Primary–Secondary Diamine Catalysts
Author(s) -
Yang YingQuan,
Zhao Gang
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200801749
Subject(s) - enantioselective synthesis , diamine , michael reaction , catalysis , primary (astronomy) , chemistry , organic chemistry , yield (engineering) , organocatalysis , combinatorial chemistry , materials science , physics , astronomy , metallurgy
Michael addition : Several novel primary–secondary diamine catalysts were readily prepared in three steps from commercially available primary amino acids. The catalysts (such as 1 ) showed excellent catalytic activity and enantioselectivity (up to 99 % yield, >99 % ee ) in the asymmetric Michael additions of malonates to enones.