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[IrCl 2 Cp*(NHC)] Complexes as Highly Versatile Efficient Catalysts for the Cross‐Coupling of Alcohols and Amines
Author(s) -
Prades Amparo,
Corberán Rosa,
Poyatos Macarena,
Peris Eduardo
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200801580
Subject(s) - catalysis , phosphine , chemistry , alkylation , cyclopentadiene , coupling reaction , medicinal chemistry , base (topology) , coupling (piping) , combinatorial chemistry , polymer chemistry , organic chemistry , materials science , mathematical analysis , mathematics , metallurgy
A comparative study on the catalytic activity of a series of [IrCl 2 Cp*(NHC)] complexes in several C–O and C–N coupling processes implying hydrogen‐borrowing mechanisms has been performed. The compound [IrCl 2 Cp*(I n Bu )] (Cp*=pentamethyl cyclopentadiene; I n Bu =1,3‐di‐ n ‐butylimidazolylidene) showed to be highly effective in the cross‐coupling reactions of amines and alcohols, providing high yields in the production of unsymmetrical ethers and N‐alkylated amines. A remarkable feature is that the processes were carried out in the absence of base, phosphine, or any other external additive. A comparative study with other known catalysts, such as Shvo's catalyst, is also reported.