Organocatalytic Approach to Benzofused Nitrogen‐Containing Heterocycles: Enantioselective Total Synthesis of (+)‐Angustureine | Zendy

Fustero Santos | Zendy; Moscardó Javier | Zendy; Jiménez Diego | Zendy; PérezCarrión María Dolores | Zendy; SánchezRoselló María | Zendy; del Pozo Carlos | Zendy

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Organocatalytic Approach to Benzofused Nitrogen‐Containing Heterocycles: Enantioselective Total Synthesis of (+)‐Angustureine

Author(s) -

Fustero Santos,

Moscardó Javier,

Jiménez Diego,

PérezCarrión María Dolores,

SánchezRoselló María,

del Pozo Carlos

Publication year - 2008

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.200801480

Subject(s) - enantioselective synthesis , chemistry , organocatalysis , organic chemistry , nitrogen , combinatorial chemistry , catalysis

Simply selective : The organocatalytic intramolecular aza‐Michael reaction (IMAMR) was employed as an enantioselective tool to generate enantiomerically enriched isoindolines, indolines, tetrahydroquinolines, and tetrahydroisoquinolines from o ‐substituted alkylidenes, anilines and benzylamines (see scheme). The methodology was applied to the synthesis of the natural product (+)‐Angustureine.

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