A Highly Enantioselective Organocatalytic Method for Reduction of Aromatic  N ‐Alkyl Ketimines | Zendy

Wang Chao | Zendy; Wu Xinjun | Zendy; Zhou Li | Zendy; Sun Jian | Zendy

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A Highly Enantioselective Organocatalytic Method for Reduction of Aromatic N ‐Alkyl Ketimines

Author(s) -

Wang Chao,

Wu Xinjun,

Zhou Li,

Sun Jian

Publication year - 2008

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.200801479

Subject(s) - trichlorosilane , enantioselective synthesis , alkyl , chemistry , chirality (physics) , reduction (mathematics) , catalysis , organic chemistry , organocatalysis , combinatorial chemistry , mathematics , physics , chiral symmetry breaking , geometry , quantum mechanics , silicon , nambu–jona lasinio model , quark

A first highly enantioselective catalytic method has been developed for the reduction of aromatic N ‐alkyl ketimines by trichlorosilane under mild conditions using the newly designed Lewis base organocatalyst 3 that incorporates C ‐ and S ‐chirality (see scheme). Excellent enantioselectivities up to 99.6 % ee and high yields were obtained for a wide range of substrates.

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