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Unprecedented Consecutive, Competitive Nucleophilic Addition to Construct Densely Functionalized Propargylic Alcohols
Author(s) -
Liu Jie,
An Yan,
Wang YaHui,
Jiang HaiYing,
Zhang YuXin,
Chen Zili
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200801452
Subject(s) - nucleophilic addition , construct (python library) , electrophile , nucleophile , tandem , alcohol , chemistry , combinatorial chemistry , computer science , organic chemistry , programming language , catalysis , materials science , composite material
Two for the price of one : A new tandem reaction involving two consecutive, competitive nucleophilic additions was developed to construct a series of densely functionalized propargylic alcohol derivatives from simple materials without functional protection, in which a variety of electrophiles including cyclopropanone and aromatic aldehydes have been successfully employed. Multiple functionalities in products 1 and 2 make them versatile structural motifs for further elaboration.