Unprecedented Consecutive, Competitive Nucleophilic Addition to Construct Densely Functionalized Propargylic Alcohols | Zendy

Liu Jie | Zendy; An Yan | Zendy; Wang YaHui | Zendy; Jiang HaiYing | Zendy; Zhang YuXin | Zendy; Chen Zili | Zendy

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Unprecedented Consecutive, Competitive Nucleophilic Addition to Construct Densely Functionalized Propargylic Alcohols

Author(s) -

Liu Jie,

An Yan,

Wang YaHui,

Jiang HaiYing,

Zhang YuXin,

Chen Zili

Publication year - 2008

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.200801452

Subject(s) - nucleophilic addition , construct (python library) , electrophile , nucleophile , tandem , alcohol , chemistry , combinatorial chemistry , computer science , organic chemistry , programming language , catalysis , materials science , composite material

Two for the price of one : A new tandem reaction involving two consecutive, competitive nucleophilic additions was developed to construct a series of densely functionalized propargylic alcohol derivatives from simple materials without functional protection, in which a variety of electrophiles including cyclopropanone and aromatic aldehydes have been successfully employed. Multiple functionalities in products 1 and 2 make them versatile structural motifs for further elaboration.

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