Premium
Radical‐Polar Crossover Domino Reaction Involving Alkynes: A Stereoselective Zinc Atom Radical Transfer
Author(s) -
PérezLuna Alejandro,
Botuha Candice,
Ferreira Franck,
Chemla Fabrice
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200801451
Subject(s) - stereoselectivity , domino , crossover , electrophile , chemistry , alkyne , reagent , zinc , polar , atom (system on chip) , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , computer science , physics , catalysis , artificial intelligence , parallel computing , astronomy
Go triple! A new domino 1,4‐addition/alkyne carbozincation has been developed with dialkylzinc reagents (see scheme). This radical‐polar crossover sequence involves a novel stereoselective radical zinc atom transfer that leads to a vinyl zinc species that can be reacted with electrophiles, thus offering a new multicomponent approach to polysubstituted alkylidene tetrahydrofurans.