Radical‐Polar Crossover Domino Reaction Involving Alkynes: A Stereoselective Zinc Atom Radical Transfer | Zendy

PérezLuna Alejandro | Zendy; Botuha Candice | Zendy; Ferreira Franck | Zendy; Chemla Fabrice | Zendy

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Radical‐Polar Crossover Domino Reaction Involving Alkynes: A Stereoselective Zinc Atom Radical Transfer

Author(s) -

PérezLuna Alejandro,

Botuha Candice,

Ferreira Franck,

Chemla Fabrice

Publication year - 2008

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.200801451

Subject(s) - stereoselectivity , domino , crossover , electrophile , chemistry , alkyne , reagent , zinc , polar , atom (system on chip) , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , computer science , physics , catalysis , artificial intelligence , parallel computing , astronomy

Go triple! A new domino 1,4‐addition/alkyne carbozincation has been developed with dialkylzinc reagents (see scheme). This radical‐polar crossover sequence involves a novel stereoselective radical zinc atom transfer that leads to a vinyl zinc species that can be reacted with electrophiles, thus offering a new multicomponent approach to polysubstituted alkylidene tetrahydrofurans.

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