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Copper‐Catalyzed Enantioselective Conjugate Addition of Dialkylzinc Reagents to α′‐Oxy Enones
Author(s) -
García Jesús M.,
González Alberto,
Kardak Bharat G.,
Odriozola José M.,
Oiarbide Mikel,
Razkin Jesús,
Palomo Claudio
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200801343
Subject(s) - conjugate , enantioselective synthesis , reagent , catalysis , chemistry , steric effects , functional group , combinatorial chemistry , enone , addition reaction , organic chemistry , mathematics , mathematical analysis , polymer
Broad tolerance : A step further in the enantioselective Cu‐catalyzed conjugate addition of R 2 Zn reagents to enoyl systems is taken by using sterically encumbered α′‐oxy enone templates (see scheme). The method constitutes an advanced entry to enantioenriched β‐branched carboxylic acids and aldehydes with a broad R 2 Zn and functional group tolerance.