Copper‐Catalyzed Enantioselective Conjugate Addition of Dialkylzinc Reagents to α′‐Oxy Enones | Zendy

García Jesús M. | Zendy; González Alberto | Zendy; Kardak Bharat G. | Zendy; Odriozola José M. | Zendy; Oiarbide Mikel | Zendy; Razkin Jesús | Zendy; Palomo Claudio | Zendy

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Copper‐Catalyzed Enantioselective Conjugate Addition of Dialkylzinc Reagents to α′‐Oxy Enones

Author(s) -

García Jesús M.,

González Alberto,

Kardak Bharat G.,

Odriozola José M.,

Oiarbide Mikel,

Razkin Jesús,

Palomo Claudio

Publication year - 2008

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.200801343

Subject(s) - conjugate , enantioselective synthesis , reagent , catalysis , chemistry , steric effects , functional group , combinatorial chemistry , enone , addition reaction , organic chemistry , mathematics , mathematical analysis , polymer

Broad tolerance : A step further in the enantioselective Cu‐catalyzed conjugate addition of R 2 Zn reagents to enoyl systems is taken by using sterically encumbered α′‐oxy enone templates (see scheme). The method constitutes an advanced entry to enantioenriched β‐branched carboxylic acids and aldehydes with a broad R 2 Zn and functional group tolerance.

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