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Cross‐Coupling Reaction between Alcohols through sp 3 CH Activation Catalyzed by a Ruthenium/Lewis Acid System
Author(s) -
Zhang ShuYu,
Tu YongQiang,
Fan ChunAn,
Jiang YiJun,
Shi Lei,
Cao Ke,
Zhang En
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200801317
Subject(s) - ruthenium , catalysis , lewis acids and bases , chemistry , coupling reaction , coupling (piping) , alcohol , lewis acid catalysis , metal , medicinal chemistry , polymer chemistry , organic chemistry , materials science , metallurgy
Only wasting water : A new transition‐metal‐catalyzed/Lewis acid mediated CC cross‐coupling reaction of various different alcohols (as green starting materials) has been realized (see scheme). A variety of functionalized alcohols could be straightforwardly synthesized in good to excellent yields through the selective activation of the sp 3 CH bond adjacent to the hydroxyl group of primary alcohols; furthermore, the only waste generated through the overall process is water.