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Phosphorescent Thymidine Triphosphate Sensor Based on a Donor–Acceptor Ensemble System using Intermolecular Energy Transfer
Author(s) -
Kwon TaeHyuk,
Kim Hee Jin,
Hong JongIn
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200801260
Subject(s) - phosphorescence , acceptor , intermolecular force , energy transfer , chemistry , transfer (computing) , photochemistry , chemical physics , computer science , physics , molecule , organic chemistry , optics , quantum mechanics , fluorescence , parallel computing
An ensemble sensor system that exhibited selective luminescence enhancement upon binding to thymidine 5′‐triphosphate (TTP) in HEPES buffer over other nucleotides was developed. The ensemble system consisted of an energy acceptor (FIrpic–bis(Zn 2+ –dipicolylamine conjugate, FIrpic=bis[(4,6‐difluorophenyl)‐pyridinato‐ N , C 2+ ]picolinate) derivative) and an energy donor (mCP–Zn 2+ –cyclen, mCP= N,N′‐ dicarbazolyl‐3,5‐benzene). Among the nucleotides, the selective recognition and luminescence enhancement for TTP was achieved by the strong binding of the thymine unit to Zn 2+ –cyclen (cyclen=1,4,7,10‐tetraazacyclododecane) and intermolecular energy transfer between the mCP and FIrpic moieties.