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Diversity‐Oriented Synthesis towards Conceptually New Highly Modular Aminal–Pyrrolidine Organocatalysts
Author(s) -
Quintard Adrien,
Bournaud Chloée,
Alexakis Alexandre
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200801212
Subject(s) - aminal , pyrrolidine , diversity (politics) , modular design , catalysis , organic chemistry , chemistry , computer science , sociology , anthropology , operating system
New family member : A conceptually new family of modular aminal–pyrrolidine organocatalysts was prepared by diversity‐oriented synthesis. The catalytic properties of these organocatalysts could easily be tuned by varying the different substituents on the aminal part. Good yields and enantioselectivities up to 91 % were obtained in Michael additions to nitroolefins or vinyl sulfones (see scheme).