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Selective Extraction of G‐Quadruplex Ligands from a Rationally Designed Scaffold‐Based Dynamic Combinatorial Library
Author(s) -
Nielsen Mads Corvinius,
Ulven Trond
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200801109
Subject(s) - combinatorial chemistry , scaffold , drug discovery , chemistry , selectivity , g quadruplex , extraction (chemistry) , computer science , chemical library , chromatography , organic chemistry , dna , biochemistry , small molecule , database , catalysis
Fishing for ligands : The power of dynamic combinatorial chemistry in drug discovery is boosted by a design principle allowing multiple scaffold substituents. Library analysis is furthermore assisted by taking advantage of the UV/Vis spectra of the scaffolds, and an active compound is extracted from the mixture with high selectivity over less active compounds (see figure).