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Efficient Assembly of Allenes, 1,3‐Dienes, and 4 H ‐Pyrans by Catalytic Regioselective Nucleophilic Addition to Electron‐Deficient 1,3‐Conjugated Enynes
Author(s) -
Yu Xiuzhao,
Ren Hongjun,
Xiao Yuanjing,
Zhang Junliang
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200801004
Subject(s) - regioselectivity , nucleophile , conjugated system , conjugate , chemistry , catalysis , polar effect , medicinal chemistry , combinatorial chemistry , organic chemistry , mathematics , mathematical analysis , polymer
Organic building blocks : From a starting material of electron‐deficient 1,3‐conjugate enynes 1 (see scheme; EWG=electron‐withdrawing group), it is possible to make three types of useful organic building blocks (1,2‐allenes, 1,3‐dienes, and 4 H ‐pyrans) regioselectively, by a simple choice of different nucleophiles.