Premium
Selective Ruthenium‐Catalyzed Hydration of Nitriles to Amides in Pure Aqueous Medium Under Neutral Conditions
Author(s) -
Cadierno Victorio,
Francos Javier,
Gimeno José
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200800847
Subject(s) - ruthenium , catalysis , aqueous medium , chemistry , aqueous solution , combinatorial chemistry , chloride , organic chemistry , nuclear chemistry
Simple, general, efficient, and green : Selective hydration of nitriles to amides (see scheme) can be performed in water under neutral conditions by using the novel hydrosoluble ruthenium(II) catalyst [RuCl 2 (η 6 ‐C 6 Me 6 )(PTA‐Bn)] (PTA‐Bn=1‐benzyl‐3,5‐diaza‐1‐azonia‐7‐phosphaadamantane chloride).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom