Premium
Asymmetric Organocatalysis: An Efficient Enantioselective Access to Benzopyranes and Chromenes
Author(s) -
Rueping Magnus,
Sugiono Erli,
Merino Estíbaliz
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200800836
Subject(s) - enantioselective synthesis , organocatalysis , chemistry , ether , catalysis , organic chemistry , combinatorial chemistry
Valuable, biologically active chromenones such as those depicted were synthesized based on a diaryl prolinol ether catalyzed, enantioselective reaction of diketones with α,β‐unsaturated aldehydes. In these efficient addition–acetalization cascade reactions, diverse aliphatic and aromatic α,β‐unsaturated aldehydes, as well as various diketones, can be successfully applied and the 2‐hydroxychromenones can be isolated in good yields and with excellent enantioselectivities.