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Synthesis and Oxidation‐Induced DNA Cross‐Linking Capabilities of Bis(catechol) Quaternary Ammonium Derivatives
Author(s) -
Song Zhibin,
Weng Xiaocheng,
Weng Liwei,
Huang Jing,
Wang Xiaolin,
Bai Minghui,
Zhou Yangyang,
Yang Guangfu,
Zhou Xiang
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200800783
Subject(s) - catechol , periodate , chemistry , combinatorial chemistry , dna , oligonucleotide , ammonium , organic chemistry , biochemistry
Design and synthesis : A series of bis(catechol) compounds has been designed and synthesized and their abilities to cross‐link plasmid DNA and oligonucleotides after periodate oxidation or tyrosinase were investigated (see graphic). The oxidative process was monitored by UV/Vis spectroscopy.