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Enabling Continuous‐Flow Chemistry in Microstructured Devices for Pharmaceutical and Fine‐Chemical Production
Author(s) -
Kockmann Norbert,
Gottsponer Michael,
Zimmermann Bertin,
Roberge Dominique M.
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200800707
Subject(s) - mass transfer , mass transport , mixing (physics) , process engineering , production (economics) , flow chemistry , nanotechnology , chemistry , biochemical engineering , materials science , continuous flow , engineering , physics , chromatography , quantum mechanics , economics , macroeconomics
Abstract Microstructured devices offer unique transport capabilities for rapid mixing, enhanced heat and mass transfer and can handle small amounts of dangerous or unstable materials. The integration of reaction kinetics into fluid dynamics and transport phenomena is essential for successful application from process design in laboratory to chemical production. Strategies to implement production campaigns up to tons of pharmaceutical chemicals are discussed, based on Lonza projects.