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Glycomimetics and Glycodendrimers as High Affinity Microbial Anti‐adhesins
Author(s) -
Imberty Anne,
Chabre Yoann M.,
Roy René
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200800700
Subject(s) - glycoconjugate , bacterial adhesin , lectin , chemistry , adhesion , glycoprotein , oligosaccharide , biofilm , biochemistry , microbiology and biotechnology , virulence , biology , bacteria , organic chemistry , genetics , gene
Abstract Adhesion to epithelial surface is often the first step in bacterial and viral infection. In this process, the microbes use a variety of proteins for interaction with host carbohydrates presented as glycoconjugates on cell surfaces. Crystal structures of adhesin and lectin binding sites in complexes with oligosaccharide open the route for design and synthesis of glycomimetics, glycodendrimers, and glycopolymers that are able to block infection at an early stage.