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Novel Bifunctional Chiral Urea and Thiourea Derivatives as Organocatalysts: Enantioselective Nitro‐Michael Reaction of Malonates and Diketones
Author(s) -
Andrés José M.,
Manzano Rubén,
Pedrosa Rafael
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200800633
Subject(s) - bifunctional , thiourea , enantioselective synthesis , michael reaction , nitro , chemistry , organocatalysis , urea , organic chemistry , combinatorial chemistry , catalysis , alkyl
Novel chiral ureas and thioureas derived form natural α‐amino acids have been prepared and tested as bifunctional organocatalysts in enantioselective nitro‐Michael additions (see scheme). The reactions occurred with excellent chemical yields and up to 99 % ee.