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Dendrimers and DNA: Combinations of Two Special Topologies for Nanomaterials and Biology
Author(s) -
Caminade AnneMarie,
Turrin CédricOlivier,
Majoral JeanPierre
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200800584
Subject(s) - dendrimer , biochip , oligonucleotide , dna , nanotechnology , dna microarray , transfection , nanomaterials , dna sequencing , materials science , computational biology , chemistry , biophysics , biology , biochemistry , gene , gene expression , polymer chemistry
Interactions between two precisely defined three‐dimensional architectures (DNA and dendrimers) are described. Highly synergetic effects occur, as illustrated in two cases: dendrimers can be used as three‐dimensional linkers for oligonucleotides, affording highly sensitive microarrays (biochips), and positively charged dendrimers strongly interact with DNA, allowing penetration inside cells (genetic transfection).