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A Shift in Retrosynthetic Paradigm
Author(s) -
Marek Ilan
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200800580
Subject(s) - stereocenter , retrosynthetic analysis , carbon fibers , quaternary carbon , reagent , enantioselective synthesis , chemistry , catalysis , combinatorial chemistry , computer science , organic chemistry , total synthesis , algorithm , composite number
The current state‐of‐the‐art synthesis for the formation of enantiomerically enriched all‐carbon quaternary stereocenters in acyclic system relies on the formation of a single carboncarbon bond per chemical step by asymmetric catalysis. These extraordinary sophisticated methods were logically classified among the most powerful and innovative ones. In this concept article, we are proposing a new retrosynthetic paradigm to solve differently such challenging problems. These new synthetic pathways lead to the diastereo‐ and enantiomerically pure formation of three new carboncarbon bonds in acyclic system, in a one‐pot reaction, including the formation of all‐carbon quaternary stereocenters by using classical reagents and experimental conditions and from common starting materials.