Direct Allylation of Aldimines Catalyzed by  C  2 ‐Symmetric  N , N′ ‐Dioxide–Sc III  Complexes: Highly Enantioselective Synthesis of Homoallylic Amines | Zendy

Li Xing | Zendy; Liu Xiaohua | Zendy; Fu Yingzi | Zendy; Wang Lijia | Zendy; Zhou Lin | Zendy; Feng Xiaoming | Zendy

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Direct Allylation of Aldimines Catalyzed by C 2 ‐Symmetric N , N′ ‐Dioxide–Sc III Complexes: Highly Enantioselective Synthesis of Homoallylic Amines

Author(s) -

Li Xing,

Liu Xiaohua,

Fu Yingzi,

Wang Lijia,

Zhou Lin,

Feng Xiaoming

Publication year - 2008

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.200800534

Subject(s) - aldimine , enantioselective synthesis , catalysis , chemistry , medicinal chemistry , organic chemistry

The first catalytic asymmetric three‐component allylation of aldimines has been developed. In the presence of L ‐ramipril acid‐oriented N , N′ ‐dioxide–Sc III complex catalyst, a range of homoallylic amines were formed in excellent enantioselectivities (up to 97 % ee ) with good yields from corresponding aldehydes, 2‐aminophenol and allyltributyltin (see scheme).

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