Premium
Direct Allylation of Aldimines Catalyzed by C 2 ‐Symmetric N , N′ ‐Dioxide–Sc III Complexes: Highly Enantioselective Synthesis of Homoallylic Amines
Author(s) -
Li Xing,
Liu Xiaohua,
Fu Yingzi,
Wang Lijia,
Zhou Lin,
Feng Xiaoming
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200800534
Subject(s) - aldimine , enantioselective synthesis , catalysis , chemistry , medicinal chemistry , organic chemistry
The first catalytic asymmetric three‐component allylation of aldimines has been developed. In the presence of L ‐ramipril acid‐oriented N , N′ ‐dioxide–Sc III complex catalyst, a range of homoallylic amines were formed in excellent enantioselectivities (up to 97 % ee ) with good yields from corresponding aldehydes, 2‐aminophenol and allyltributyltin (see scheme).