Highly Enantioselective Strecker Reaction of Ketoimines Catalyzed by an Organocatalyst from ( S )‐BINOL and  L ‐Prolinamide | Zendy

Hou Zongrui | Zendy; Wang Jun | Zendy; Liu Xiaohua | Zendy; Feng Xiaoming | Zendy

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Highly Enantioselective Strecker Reaction of Ketoimines Catalyzed by an Organocatalyst from ( S )‐BINOL and L ‐Prolinamide

Author(s) -

Hou Zongrui,

Wang Jun,

Liu Xiaohua,

Feng Xiaoming

Publication year - 2008

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.200800454

Subject(s) - chemistry , enantioselective synthesis , scope (computer science) , strecker amino acid synthesis , catalysis , organocatalysis , substrate (aquarium) , organic chemistry , stereochemistry , computer science , oceanography , geology , programming language

A novel and efficient organocatalyst was developed to promote the Strecker reaction of ketoimines (see scheme). Wide substrate scope and excellent enantioselectivities (up to 99 % ee ) were obtained with low catalyst loading (2 mol %) under mild reaction conditions.

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