Premium
Highly Enantioselective Strecker Reaction of Ketoimines Catalyzed by an Organocatalyst from ( S )‐BINOL and L ‐Prolinamide
Author(s) -
Hou Zongrui,
Wang Jun,
Liu Xiaohua,
Feng Xiaoming
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200800454
Subject(s) - chemistry , enantioselective synthesis , scope (computer science) , strecker amino acid synthesis , catalysis , organocatalysis , substrate (aquarium) , organic chemistry , stereochemistry , computer science , oceanography , geology , programming language
A novel and efficient organocatalyst was developed to promote the Strecker reaction of ketoimines (see scheme). Wide substrate scope and excellent enantioselectivities (up to 99 % ee ) were obtained with low catalyst loading (2 mol %) under mild reaction conditions.