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Ligand‐Free Sonogashira Coupling Reactions with Heterogeneous Pd/C as the Catalyst
Author(s) -
Mori Shigeki,
Yanase Takayoshi,
Aoyagi Satoka,
Monguchi Yasunari,
Maegawa Tomohiro,
Sajiki Hironao
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200800387
Subject(s) - sonogashira coupling , catalysis , ligand (biochemistry) , aryl , chemistry , amine gas treating , aqueous medium , salt (chemistry) , aqueous solution , copper , combinatorial chemistry , coupling reaction , palladium , heterogeneous catalysis , medicinal chemistry , organic chemistry , polymer chemistry , alkyl , receptor , biochemistry
A variety of aryl iodides were coupled with aromatic and aliphatic terminal alkynes to give the corresponding 1,2‐disubstituted aromatic alkynes in good yields by using only 0.4 mol % of the heterogeneous 10 % Pd/C as the catalyst without a ligand, copper salt, or amine in an aqueous medium.
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