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Tandem Intramolecular Hydroalkoxylation–Hydroarylation Reactions: Synthesis of Enantiopure Benzofused Cyclic Ethers from the Chiral Pool
Author(s) -
Barluenga José,
Fernández Amadeo,
Satrústegui Amaya,
Diéguez Alejandro,
Rodríguez Félix,
Fañanás Francisco J.
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200800312
Subject(s) - enantiopure drug , tandem , intramolecular force , chemistry , catalysis , aryl , combinatorial chemistry , stereochemistry , medicinal chemistry , enantioselective synthesis , organic chemistry , materials science , alkyl , composite material
Progressive cycling! Highly functionalized benzofused oxabicyclo[3.3.1]nonanes are easily obtained from simple aryl‐substituted alquinol derivatives by a catalytic tandem sequence involving an hydroalkoxylation reaction followed by a hydroarylation process, shown here.