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Iron‐Catalyzed N ‐Arylations of Amides
Author(s) -
Correa Arkaitz,
Elmore Simon,
Bolm Carsten
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200800293
Subject(s) - catalysis , aryl , environmentally friendly , ligand (biochemistry) , diamine , combinatorial chemistry , chemistry , primary (astronomy) , in situ , organic chemistry , physics , ecology , biochemistry , alkyl , receptor , astronomy , biology
Iron can do it too! A novel, experimentally simple procedure for the N ‐arylation of primary amides with aryl iodides involving an in situ formed iron‐based catalyst is reported. The success of the reaction relies on the use of cheap and environmentally friendly FeCl 3 in combination with an inexpensive diamine ligand as catalyst system (see scheme).